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Compare mechanisms, Phase 2 outcomes, and research applications

Reduced pain and improved function after substantial weight loss are consistent with both osteoarthritis and inflammatory arthritis improvements seen in studies

Measured height and weight with dates, a calculated body mass index consistent with the labeled population, diagnosis codes for every weight-related condition, and evidence of a prior structured attempt at diet and physical activity

Prostaglandins, Leukotrienes and Essential Fatty Acids 79 , 153156, doi:10.1016/j.plefa.2008.09.010 (2008)